Specific Association of HLA-DRB1*03 With Anti-Carbamylated Protein Antibodies in Patients With Rheumatoid Arthritis.

Cristina RegueiroLuis Rodriguez-RodriguezAna Triguero-MartinezLaura NuñoAngel L Castaño-NuñezAlejandro VillalvaEva Perez-PampinYolanda Lopez-GolanLydia AbasoloAna M OrtizEva HerranzDora Pascual-SalcedoAna Martínez-FeitoMaría Dolores BovedaJuan J Gomez-ReinoJavier MartínMaría Francisca Gonzalez-EscribanoBenjamín Fernandez-GutierrezAlejandro BalsaIsidoro González-Alvaro Antonio González

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2019)

These findings indicate a specific association of HLA-DRB1*03 with ACPA-/anti-CarP+ RA, suggesting that preferential presentation of carbamylated peptides could be a new mechanism underlying the contribution of HLA alleles to RA susceptibility.

Keyphrases

rheumatoid arthritis
disease activity
ankylosing spondylitis
amino acid
small molecule
protein protein