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Novel highly potent OXE receptor antagonists with prolonged plasma lifetimes that are converted to active metabolites in vivo in monkeys.

Qiuji YeShishir ChoureyChintam Nagendra ReddyRui WangChantal CossetteSylvie GravelIrina SlobodchikovaDajana VuckovicJoshua RokachWilliam S Powell
Published in: British journal of pharmacology (2020)
Because of its highly potent antagonist activity and its long lifetime in vivo, S-Y048 may be a useful anti-inflammatory agent for the treatment of eosinophilic diseases such as asthma, allergic rhinitis, and atopic dermatitis.
Keyphrases
  • allergic rhinitis
  • anti inflammatory
  • atopic dermatitis
  • ms ms
  • chronic obstructive pulmonary disease
  • lung function
  • air pollution