Blockage of EGFR/AKT and mevalonate pathways synergize the antitumor effect of temozolomide by reprogramming energy metabolism in glioblastoma.
Xiaoteng CuiJixing ZhaoGuanzhang LiChao YangShixue YangQi ZhanJunhu ZhouYunfei WangMenglin XiaoBiao HongKaikai YiFei TongYanli TanHu WangQixue WangTao JiangChuan FangChun-Sheng KangPublished in: Cancer communications (London, England) (2023)
Our findings not only uncovered the mechanism of metabolic reprogramming in EGFR-activated GBM but also provided a combinatorial therapeutic strategy for clinical GBM management.