Water-Soluble Non-Classical Benzene Mimetics.
Vadym V LevterovYaroslav PanasyukValentyna O PivnytskaPavel K MykhailiukPublished in: Angewandte Chemie (International ed. in English) (2020)
A new generation of saturated benzene mimetics, 2-oxabicyclo[2.1.1]hexanes, was developed. These compounds were designed as analogues of bicyclo[1.1.1]pentane with an improved water solubility. Crystallographic analysis of 2-oxabicyclo[2.1.1]hexanes revealed that they occupy a novel chemical space, but, at the same time, resemble the motif of meta-disubstituted benzenes.