Association of strong risk of hTERT gene polymorphic variants to malignant glioma and its prognostic implications with respect to different histological types and survival of glioma cases.

Arshad A PandithZahoor A WaniIqbal QasimDil AfrozeUsma ManzoorIna AminShahid M BabaAabid KoulIqra AnwarFozia MohammadAbdul R BhatParveen Shah

Published in: The journal of gene medicine (2020)

The results of the present study indicate that hTERT rs2736098 and rs2736100 variants play an important role in conferring a strong risk of developing glioma. Furthermore, hTERT rs2736100 GG variant appears to play a role in the bad prognosis of glioma patients. Haplotypes GG and GA could prove to be vital tools for monitoring risk in glioma patients.

Keyphrases

end stage renal disease
newly diagnosed
chronic kidney disease
copy number
prognostic factors
patient reported