Targeting integrin α5 in fibroblasts potentiates colorectal cancer response to PD-L1 blockade by affecting extracellular-matrix deposition.

Ling LuYaohui GaoDengfeng HuangHu LiuDingzi YinMan LiJiayi ZhengShufei WangWeijun WuLi ZhaoDexi BiYouhua ZhangFeifei SongRuting XieJifeng WangHuanlong QinQing Wei

Published in: Journal for immunotherapy of cancer (2023)

Our study identified a role for integrin α5 in fibroblasts in modulating antitumor immunity by affecting ECM deposition and showed therapeutic efficacy for combined α5β1 inhibition and PD-L1 blockade in CRC.

Keyphrases

extracellular matrix
signaling pathway
cell adhesion
cell migration