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Loss of signal transducer and activator of transcription 3 impaired the osteogenesis of mesenchymal progenitor cells in vivo and in vitro.

Zijing HuangJingyi FengXin FengLaiting ChanJiarui LuLizhen LeiZhuwei HuangXiaolei Zhang
Published in: Cell & bioscience (2021)
Stat3 played a critical role in bone development and osteogenesis. Loss of Stat3 impaired the osteogenesis of mesenchymal progenitors in vivo and in vitro.
Keyphrases
  • bone regeneration
  • bone marrow
  • stem cells
  • cell proliferation
  • bone mineral density
  • nuclear factor
  • soft tissue
  • immune response
  • body composition
  • postmenopausal women
  • inflammatory response
  • bone loss