TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation.
Lorenza MagnoTom D BunneyEmma MeadFredrik SvenssonMagda N BictashPublished in: Molecular neurodegeneration (2021)
The central role of the resident innate immune cells of the brain (microglia) in neurodegeneration has become clear over the past few years largely through genome-wide association studies (GWAS), and has rapidly become an active area of research. However, a mechanistic understanding (gene to function) has lagged behind. That is now beginning to change, as exemplified by a number of recent exciting and important reports that provide insight into the function of two key gene products - TREM2 (Triggering Receptor Expressed On Myeloid Cells 2) and PLCγ2 (Phospholipase C gamma2) - in microglia, and their role in neurodegenerative disorders. In this review we explore and discuss these recent advances and the opportunities that they may provide for the development of new therapies.
Keyphrases
- genome wide association
- inflammatory response
- immune response
- induced apoptosis
- copy number
- genome wide
- neuropathic pain
- bone marrow
- dendritic cells
- emergency department
- gene expression
- dna methylation
- cell proliferation
- signaling pathway
- spinal cord injury
- endoplasmic reticulum stress
- subarachnoid hemorrhage
- brain injury