Association of plasma docetaxel levels with ABCB1 gene polymorphisms and tumour response in locally advanced breast cancer patients of South India on neo-adjuvant chemotherapy.
Rekha PriyadarshiniGerard Marshall RajRajan SundaramSmita KayalAnanthakrishnan RameshDeepak Gopal ShewadePublished in: Breast cancer (Tokyo, Japan) (2020)
The plasma levels of docetaxel were significantly influenced by the SNP C1236T of ABCB1 gene coding for the MDR1 transporter (P-glycoprotein). The plasma levels of docetaxel were also found to influence its therapeutic effect.