Determinants of treatment-related paradoxical reactions during anti-tuberculosis therapy: a case control study.
Colin Stewart BrownColette Joanne SmithRonan Angus MacCormick BreenLawrence Peter OrmerodRahul MittalMarie FiskHeather June MilburnNicholas Martin PriceGraham Henry BothamleyMarc Caeroos Isaac LipmanPublished in: BMC infectious diseases (2016)
HIV was strongly associated with PR. The increased potential for PR in people with culture positive TB suggests that host mycobacterial burden might be relevant. The increased risk with TB lymphadenitis may in part arise from the visibility of clinical signs at this site. Non-HIV immunosuppression may have a protective effect. This study highlights the difficulties in predicting PR using routinely available demographic details, clinical symptoms or biochemical markers.
Keyphrases
- mycobacterium tuberculosis
- antiretroviral therapy
- hiv positive
- hiv aids
- hiv infected
- human immunodeficiency virus
- hiv testing
- hepatitis c virus
- men who have sex with men
- pulmonary tuberculosis
- stem cells
- physical activity
- risk factors
- mesenchymal stem cells
- risk assessment
- sleep quality
- adverse drug
- cell therapy
- drug induced
- replacement therapy