A Population Pharmacokinetic Modelling Approach to Unravel the Complex Pharmacokinetics of Vincristine in Children.
A Laura NijstadWan-Yu ChuEvelien de Vos-KerkhofCatherine F Enters-WeijnenMirjam E van de VeldeGertjan J L KaspersShelby BarnettGareth J VealArief LalmohamedC Michel ZwaanAlwin D R HuitemaPublished in: Pharmaceutical research (2022)
A decrease of vincristine β-tubulin binding capacity with increasing age suggests that young children tolerate higher doses of vincristine.