Direct Conversion of 3-(2-Nitroethyl)-1H-Indoles into 2-(1H-Indol-2-yl)Acetonitriles.
Alexander V AksenovNicolai A AksenovElena V AleksandrovaDmitrii A AksenovIgor Yu GrishinElena A SorokinaAllison WengerMichael RubinPublished in: Molecules (Basel, Switzerland) (2021)
The recently discovered [4+1]-spirocyclization of nitroalkenes to indoles provided a convenient new approach to 2-(1H-indol-2-yl)acetonitriles. However, this reaction was complicated by the formation of inert 3-(2-nitroethyl)-1H-indole byproducts. Herein, we offer a workaround this problem that allows for effective transformation of the unwanted byproducts into acetonitrile target molecules.
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