Iron Oxide-Based Magneto-Optical Nanocomposites for In Vivo Biomedical Applications.
Nisha LamichhaneShalini Sharmanull ParulAnita Kamra VermaIndrajit RoyTapas SenPublished in: Biomedicines (2021)
Iron oxide nanoparticles (IONPs) have played a pivotal role in the development of nanomedicine owing to their versatile functions at the nanoscale, which facilitates targeted delivery, high contrast imaging, and on-demand therapy. Some biomedical inadequacies of IONPs on their own, such as the poor resolution of IONP-based Magnetic Resonance Imaging (MRI), can be overcome by co-incorporating optical probes onto them, which can be either molecule- or nanoparticulate-based. Optical probe incorporated IONPs, together with two prominent non-ionizing radiation sources (i.e., magnetic field and light), enable a myriad of biomedical applications from early detection to targeted treatment of various diseases. In this context, many research articles are in the public domain on magneto-optical nanoparticles; discussed in detail are fabrication strategies for their application in the biomedical field; however, lacking is a comprehensive review on real-life applications in vivo, their toxicity, and the prospect of bench-to-bedside clinical studies. Therefore, in this review, we focused on selecting such important nanocomposites where IONPs become the magnetic component, conjugated with various types of optical probes; we clearly classified them into class 1 to class 6 categories and present only in vivo studies. In addition, we briefly discuss the potential toxicity of such nanocomposites and their respective challenges for clinical translations.
Keyphrases
- high resolution
- magnetic resonance imaging
- high speed
- contrast enhanced
- small molecule
- living cells
- single molecule
- healthcare
- reduced graphene oxide
- atomic force microscopy
- computed tomography
- fluorescence imaging
- magnetic resonance
- carbon nanotubes
- cancer therapy
- emergency department
- stem cells
- photodynamic therapy
- mass spectrometry
- drinking water
- drug delivery
- mesenchymal stem cells
- risk assessment
- low cost
- cell therapy
- molecularly imprinted
- nucleic acid
- electronic health record