Intravenous delivery of granulocyte-macrophage colony stimulating factor impairs survival in lipopolysaccharide-induced sepsis.

Jörg KrebsAlexander HillenbrandCharalambos TsagogiorgasChristian PatryBurkhard TönshoffBenito YardGrietje BeckNeysan Rafat

Published in: PloS one (2019)

GM-CSF did not have a beneficial effect on the clinical course in our LPS-induced sepsis model. It synergistically promoted inflammation with LPS and probably thereby impaired survival.

Keyphrases

inflammatory response
lipopolysaccharide induced
lps induced
acute kidney injury
septic shock
intensive care unit
oxidative stress
free survival
adipose tissue
cerebrospinal fluid