A novel process driving Alzheimer's disease validated in a mouse model: Therapeutic potential.
Susan A GreenfieldGregory M ColeClive W CoenSally A FrautschyRam P SinghMarisa MekkittikulSara Garcia-RatésPaul MorrillOwen HollingsMatt PassmoreSibah HasanNikisha CartySilvia BisonLaura PiccoliRenzo CarlettiStephano TacconiAnna ChalidouMatthew PederciniTim KroecherHubert AstnerPhilip A GerrardPublished in: Alzheimer's & dementia (New York, N. Y.) (2022)
These findings indicate that the T14 system, for which the signaling pathway is described here, contributes to the neuropathological process and that NBP14 warrants consideration for its therapeutic potential.