Neutralising reactivity against SARS-CoV-2 Delta and Omicron variants by vaccination and infection history.
Enrico LavezzoMonia PacentiLaura ManutoCaterina BoldrinMargherita CattaiMarco GrazioliFederico BiancaMargherita SartoriFederico CaldartGioele CastelliMichele NicolettiEleonora NiedduElisa SalvadorettiBeatrice LabellaLudovico FavaMaria Cristina VanuzzoVittoria LisiMaria AntonelloCarmela Ileana GrimaldiChiara ZulianClaudia Del VecchioMario PlebaniAndrea PadoanDaniela Maria CirilloAlessandra R BrazzaleGiovanni TononStefano ToppoIlaria DorigattiAndrea CrisantiPublished in: Genome medicine (2022)
These results confirm that vaccination induces strong antibody response in most individuals, and even stronger in previously infected subjects. Neutralising reactivity elicited by natural infection followed by vaccination is increasingly weakened by the recent emergence of VOCs. While immunity is not completely compromised, a change in vaccine development may be required going forward, to generate cross-protective pan-coronavirus immunity in the global population.