Genome-wide analysis indicates association between heterozygote advantage and healthy aging in humans.
Ke XuRoman KosoyKhader ShameerSudhir KumarLi LiuBen ReadheadGillian M BelbinHao-Chih LeeRong ChenJoel T DudleyPublished in: BMC genetics (2019)
Our results demonstrate that the genomic heterozygosity is associated with human healthspan, and that the relationship between higher heterozygosity and healthy aging could be explained by heterozygote advantage. Further characterization of this relationship will have important implications in aging-associated disease risk prediction.