A core Nrf2 gene set defined through comprehensive transcriptomic analysis predicts drug resistance and poor multi-cancer prognosis.
George LuoHarshita KumarKristin AldridgeStevie RiegerEthan JiangErnest R ChanAhmed SolimanHaider MahdiJohn J LetterioPublished in: bioRxiv : the preprint server for biology (2023)
The frequent activation of Nrf2 observed in cancer cells confers protection from oxidative stress, cytotoxic chemotherapeutic agents and radiation. We define a 'Nrf2 gene signature' that is comprised of 14 target genes and faithfully predicts increased Nrf2 activity, selective drug and radiation resistance in cancer cell lines, and a worse clinical prognosis in a variety of human cancers.
Keyphrases
- oxidative stress
- papillary thyroid
- genome wide
- genome wide identification
- squamous cell
- endothelial cells
- ischemia reperfusion injury
- copy number
- dna damage
- diabetic rats
- induced apoptosis
- radiation induced
- dna methylation
- emergency department
- gene expression
- transcription factor
- lymph node metastasis
- genome wide analysis
- young adults
- heat shock