Enhancing intracellular cholesterol efflux in chondrocytes alleviates osteoarthritis progression.
Gyuseok LeeJiye YangSu-Jin KimThanh-Tam TranSun Young LeeKa Hyon ParkSeung-Hee KwonKi-Ho ChungJeong-Tae KohYun Hyun HuhJong Keun SeonHyun Ah KimJang-Soo ChunJe-Hwang RyuPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2024)
Our results suggest that restoration of cholesterol homeostasis to a normal state through administration of fenofibrate or AIBP overexpression, both of which induce cholesterol efflux, offers an effective therapeutic option for OA.