MRI assessment of coronary microvascular endothelial nitric oxide synthase function using myocardial T1 mapping.
Sophia X CuiFrederick H EpsteinPublished in: Magnetic resonance in medicine (2017)
NOS inhibition causes an increase in myocardial T1 in healthy mice, and this effect is mediated through eNOS. T1 mapping during NOS inhibition detects coronary microvascular eNOS dysfunction in high-fat-diet mice. T1 mapping during NOS inhibition may be useful in preclinical studies aiming to investigate mechanisms underlying and therapies for coronary microvascular eNOS dysfunction. Magn Reson Med 79:2246-2253, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Keyphrases
- nitric oxide synthase
- nitric oxide
- high fat diet
- coronary artery disease
- coronary artery
- magnetic resonance
- high resolution
- insulin resistance
- left ventricular
- high fat diet induced
- adipose tissue
- high density
- oxidative stress
- contrast enhanced
- magnetic resonance imaging
- aortic stenosis
- stem cells
- type diabetes
- heart failure
- computed tomography
- skeletal muscle
- transcatheter aortic valve replacement
- cell therapy
- mesenchymal stem cells
- aortic valve
- wild type
- signaling pathway
- case control