Microglia in frontotemporal lobar degeneration with progranulin or C9ORF72 mutations.

Nobutaka SakaeShanu F RoemerKevin F BieniekMelissa E MurrayMatthew C BakerKoji KasanukiNeill R Graff-RadfordLeonard PetrucelliMarka Van BlitterswijkRosa RademakersGourisankar Ghosh

Published in: Annals of clinical and translational neurology (2019)

Our findings underscore differences in microglial response in FTLD-C9ORF72 and FTLD-GRN as shown by significant differences in ameboid microglia in gray and white matter. These results suggest the differential contribution of microglial dysfunction in FTLD-GRN and FTLD-C9ORF72 and suggest that clinical, neuroimaging and pathologic differences could in part be related to differences in microglia response.

Keyphrases

inflammatory response
neuropathic pain
white matter
lipopolysaccharide induced
lps induced
oxidative stress
spinal cord injury
radiation therapy
locally advanced