Monoamine Oxidases as Potential Contributors to Oxidative Stress in Diabetes: Time for a Study in Patients Undergoing Heart Surgery.
Oana M DuicuRodica LighezanAdrian SturzaRaluca A CeausuClaudia BorzaAdrian O VaduvaLavinia NoveanuMarian GasparAdina IonacHorea FeierDanina M MunteanCristian MornosPublished in: BioMed research international (2015)
Oxidative stress is a pathomechanism causally linked to the progression of chronic cardiovascular diseases and diabetes. Mitochondria have emerged as the most relevant source of reactive oxygen species, the major culprit being classically considered the respiratory chain at the inner mitochondrial membrane. In the past decade, several experimental studies unequivocally demonstrated the contribution of monoamine oxidases (MAOs) at the outer mitochondrial membrane to the maladaptative ventricular hypertrophy and endothelial dysfunction. This paper addresses the contribution of mitochondrial dysfunction to the pathogenesis of heart failure and diabetes together with the mounting evidence for an emerging role of MAO inhibition as putative cardioprotective strategy in both conditions.
Keyphrases
- oxidative stress
- cardiovascular disease
- heart failure
- type diabetes
- reactive oxygen species
- glycemic control
- patients undergoing
- dna damage
- left ventricular
- diabetic rats
- induced apoptosis
- minimally invasive
- coronary artery bypass
- human health
- cardiovascular risk factors
- adipose tissue
- coronary artery disease
- surgical site infection
- cardiac resynchronization therapy
- weight loss
- climate change