Login / Signup

TBX2-positive cells represent a multi-potent mesenchymal progenitor pool in the developing lung.

Irina WojahnTimo H LüdtkeVincent M ChristoffelsMark-Oliver TroweAndreas Kispert
Published in: Respiratory research (2019)
The fate of pulmonary mesenchymal progenitors is largely independent of TBX2. Nevertheless, a successive and precisely timed downregulation of TBX2 is necessary to allow proper differentiation and functionality of bronchial smooth muscle cells and to limit endothelial differentiation. Our work suggests expression of TBX2 in an early pulmonary mesenchymal progenitor and supports a role of TBX2 in maintaining the precursor state of these cells.
Keyphrases
  • induced apoptosis
  • bone marrow
  • stem cells
  • cell cycle arrest
  • pulmonary hypertension
  • signaling pathway
  • cell proliferation
  • endoplasmic reticulum stress
  • cell death
  • oxidative stress
  • endothelial cells
  • pi k akt