Preeclampsia and intrauterine growth restriction: Role of human umbilical cord mesenchymal stem cells-trophoblast cross-talk.
Daniela SuricoValerio BordinoVincenzo CantaluppiDavid MarySergio GentilliAlberto OldaniSerena FarruggioCarmela MelluzzaGiulia RainaElena GrossiniPublished in: PloS one (2019)
Our findings support that hUMSCs taken from patients affected by PE and IUGR have significant features in comparison with those from physiologic pregnancies. Moreover, the cross-talk between hUMSCs and trophoblast cells might be involved in the etiopathology of IUGR and PE secondary to oxidative stress.
Keyphrases
- mesenchymal stem cells
- umbilical cord
- oxidative stress
- induced apoptosis
- end stage renal disease
- ejection fraction
- endothelial cells
- newly diagnosed
- chronic kidney disease
- bone marrow
- prognostic factors
- early onset
- dna damage
- peritoneal dialysis
- cell cycle arrest
- preterm birth
- cell proliferation
- ischemia reperfusion injury
- diabetic rats
- pregnant women
- signaling pathway
- clinical evaluation