Tumor genomic, transcriptomic, and immune profiling characterizes differential response to first-line platinum chemotherapy in high grade serous ovarian cancer.

Johanne I WeberpalsTrevor J PughPaola Marco-CasanovaGlenwood D GossNatalie Andrews WrightPrisni RathJonathon TorchiaAlexander FortunaGemma N JonesMartine P RoudierLaurence BernardBryan LoDax TortiAlberto LeonKayla MarshDarren HodgsonMarc DuciaumeWilliam J HowatNatalia LukashchukStanley E LazicDoreen WhelanHarmanjatinder S Sekhon

Published in: Cancer medicine (2021)

Our research demonstrates that tumors from HGSOC patients responding poorly to first line chemotherapy have a distinct molecular profile characterized by actionable drug targets including PARP4.

Keyphrases

high grade
end stage renal disease
low grade
single cell
chronic kidney disease
newly diagnosed
ejection fraction
dna damage
locally advanced
prognostic factors
peritoneal dialysis
dna repair
patient reported outcomes
rna seq
emergency department
single molecule
gene expression