Characterisation of the in vivo interactions between detomidine and methadone in horses: Pharmacokinetic and pharmacodynamic modelling.

Miguel Gozalo-MarcillaS P L LunaR Moreira da SilvaN CrosignaniN P LopesP M TaylorL Pelligand

Published in: Equine veterinary journal (2018)

Different PK/PD interactions were demonstrated for each PD parameter and could be modelled in vivo. The modelling of our data will allow us to simulate and predict the effect of constant rate infusions of both drugs for future investigations.

Keyphrases

electronic health record
current status
big data
machine learning
drug induced
deep learning