Activation of Angiopoietin-Tie2 Signaling Protects the Kidney from Ischemic Injury by Modulation of Endothelial-Specific Pathways.

Yanyang Li Pan LiuYalu ZhouHiroshi MaekawaJohn B SilvaMohammed Javeed AnsariKhaled BoubesYazan AliaDilip K DebBenjamin R Thomson Jing Jin Susan E Quaggin

Published in: Journal of the American Society of Nephrology : JASN (2023)

Our data support a key role of the endothelium in the development of IR-AKI, introduce Hepta-ANG1 as a putative new therapeutic biologic, and report a model to explain how IRI reduces Tie2 signaling and how Tie2 activation protects the kidney.

Keyphrases

rheumatoid arthritis
acute kidney injury
nitric oxide
endothelial cells
angiotensin ii
electronic health record
big data
ischemia reperfusion injury
oxidative stress
machine learning
cerebral ischemia