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Past antihypertensive medication use is associated with lower levels of small vessel disease and lower Aβ plaque stage in the brains of older individuals.

Andrew J AffleckPerminder S SachdevGlenda M Halliday
Published in: Neuropathology and applied neurobiology (2023)
This histopathological study provides further evidence that antihypertensive medication use in older individuals is associated with white matter SVD and not with other CVD pathologies. This is mainly due to a reduction in white matter perivascular dilation and rarefaction/oedema. Even in those with moderate to severe white matter SVD, antihypertensive medication use reduced rarefaction and Aβ propagation through the brain.
Keyphrases
  • white matter
  • blood pressure
  • multiple sclerosis
  • hypertensive patients
  • community dwelling
  • physical activity
  • middle aged
  • coronary artery disease
  • early onset
  • high intensity
  • functional connectivity