Anemia is a condition in which the body has fewer red blood cells than normal. Chronic kidney disease (CKD) patients are people with permanent or partial loss of kidney functions. Renal Anemia affects patients with CKD. Knowing the prevalence of anemia among CKD patients is important for patients' treatment as well as further investigation of root cause of anemia in CKD patients. The aim of this study is to assess the prevalence of anemia among CKD at the renal outpatient department unit of St. Paulo's Hospital Millennium Medical College, Addis Ababa, Ethiopia. A retrospective study was conducted to collect the data of CKD patients from March 2016 to April 2018 at St. Paulo's Hospital Millennium Medical College. Data were collected using structural data collection and analyzed using IBM SPSS Statistics version 20.0 software. P value is used to assess the association of variables. A total of 352 CKD patients were involved in this study. The prevalence of anemia was 65.91% among CKD patients at St. Paulo's Millennium Medical College Hospital. Diabetes and hypertension (HTN) are high in anemic CKD patients 33.81% and 36.36%, respectively. Majority of these anemic CKD patients were from residency of rural areas (35.23%) and within the age group of 49-58 years (67.3%). There is a high prevalence of anemia among chronic kidney patients which is 65.91% among CKD patients. Among anemic patients, diabetes and HTN are high, and these could be risk factors for anemia. However, it needs further investigations to determine cause-effect relationship.