Biased visibility in Hi-C datasets marks dynamically regulated condensed and decondensed chromatin states genome-wide.
Keerthivasan Raanin ChandradossPrashanth Kumar GuthikondaSrinivas KethavathMonika DassHarpreet SinghRakhee NayakSreenivasulu KurukutiKuljeet Singh SandhuPublished in: BMC genomics (2020)
Our observations suggest that the corrected one-dimensional read counts of existing Hi-C datasets can be reliably repurposed to study the gene-regulatory dynamics associated with chromatin condensation and decondensation, and that the existing Hi-C datasets should be interpreted with cautions.