Accelerated Aging after Traumatic Brain Injury: An ENIGMA Multi-Cohort Mega-Analysis.
Emily Larson DennisSamantha VervoordtMaheen M AdamsonAmiri HoushangErin D BiglerKaren CaeyenberghsJames H ColeKristen Dams-O'ConnorEvelyn M DeutscherEkaterina DobryakovaHelen M GenovaJordan H GrafmanAsta K HåbergTorgeir HellstrømAndrei IrimiaVassilis E KoliatsosHannah M LindseyAbigail LivnyDavid K MenonTricia L MerkleyAbdalla Z MohamedStefania MondelloMartin Max MontiVirginia F J NewcombeMary R NewsomeJennie PonsfordAmanda RabinowitzHanne SmevikGershon SpitzUmesh M VenkatesanLars T WestlyeRoss ZafontePaul M ThompsonElisabeth A WildeAlexander OlsenFrank G HillaryPublished in: Annals of neurology (2024)
This work provides evidence that changes in brain structure after cmsTBI are dynamic, with an initial period of change, followed by relative stability in brain morphometry, eventually leading to further changes in the decades after a single cmsTBI. ANN NEUROL 2024;96:365-377.