Engineered Hybrid Treg-Targeted Nanosomes Restrain Lung Immunosuppression by Inducing Intratumoral CD8 + T Cell Immunity.

Kalliopi DomvriSavvas PetanidisPaul ZarogoulidisDoxakis AnestakisCharalampos CharalampidisDrosos TsavlisHaidong HuangLutz FreitagWolfgang Hohenforst-SchmidtDimitris MatthaiosTheodora KatopodiKonstantinos Porpodis

Published in: International journal of nanomedicine (2022)

Overall, our findings present a novel nano-enabled platform for the inhibition of Treg-dependent immunosuppression in NSCLC and provide a novel nanotherapeutic strategy for the treatment of metastatic neoplasia.

Keyphrases

small cell lung cancer
squamous cell carcinoma

high grade
high throughput

cancer therapy
advanced non small cell lung cancer

single cell
smoking cessation