Engineered Hybrid Treg-Targeted Nanosomes Restrain Lung Immunosuppression by Inducing Intratumoral CD8 + T Cell Immunity.
Kalliopi DomvriSavvas PetanidisPaul ZarogoulidisDoxakis AnestakisCharalampos CharalampidisDrosos TsavlisHaidong HuangLutz FreitagWolfgang Hohenforst-SchmidtDimitris MatthaiosTheodora KatopodiKonstantinos PorpodisPublished in: International journal of nanomedicine (2022)
Overall, our findings present a novel nano-enabled platform for the inhibition of Treg-dependent immunosuppression in NSCLC and provide a novel nanotherapeutic strategy for the treatment of metastatic neoplasia.