Association of CYP3A4-392A/G, CYP3A5-6986A/G, and ABCB1-3435C/T Polymorphisms with Tacrolimus Dose, Serum Concentration, and Biochemical Parameters in Mexican Patients with Kidney Transplant.
Edith Viridiana Alatorre-MorenoSaldaña-Cruz Ana MiriamPerez-Guerrero Edsaul EmilioMaría Cristina Morán-MoguelBetsabé Contreras-HaroDavid Alejandro López-de La MoraIngrid Patricia Dávalos-RodríguezAlejandro Marín-MedinaAlicia Rivera-CamerasLuz-Ma Adriana Balderas-PeñaJosé Juan Gómez-RamosLaura Cortes-SanabriaMario Salazar-PáramoPublished in: Genes (2024)
The findings of this study of the Mexican population showed that CYP3A5-6986 A/G GG genotype is associated with a four-fold increase in the likelihood of encountering a TAC concentration of more than 15 ng/dL. The co-occurrence of the CYP3A5-6986GG genotype and the use of drugs that increase TAC concentration correlates with a nine-fold increased risk of experiencing a TAC at a level above 15 ng/mL. Therefore, these patients have an increased susceptibility to TAC-associated toxicity.