YY1 complex in M2 macrophage promotes prostate cancer progression by upregulating IL-6.

Saisai ChenKai LuYue HouZonghao YouChuanjun ShuXiaoying WeiTiange WuNaipeng ShiGuangyuan ZhangJianping WuShuqiu ChenLihua ZhangWenchao LiDingxiao ZhangShenghong JuMing ChenBin Xu

Published in: Journal for immunotherapy of cancer (2023)

Phase separation of the YY1 complex in M2 macrophages upregulated IL-6 by promoting IL-6 enhancer-promoter interactions, thereby increasing PCa progression.

Keyphrases

prostate cancer
transcription factor
dna methylation
adipose tissue
gene expression
radical prostatectomy
binding protein