Higher midlife CAIDE score is associated with increased brain atrophy in a cohort of cognitively healthy middle-aged individuals.

Xulin Liu Maria-Eleni DounaviKaren RitchieKatie WellsCraig W RitchieLi SuGraciela Muniz-TerreraJohn T O'Brien

Published in: Journal of neurology (2021)

This study demonstrated accelerated GM atrophy concentrated in several AD signature cortical regions in healthy middle-aged subjects with high CAIDE scores.

Keyphrases

middle aged
white matter
cognitive decline
resting state
functional connectivity
cerebral ischemia