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Swertiamarin-mediated immune modulation/adaptation confers protection against <i>Plasmodium berghei</i>.

Naisargee PatelAarushi ZinzuvadiaMitali PrajapatiRajeev K TyagiSarat Kumar Dalai
Published in: Future microbiology (2022)
<b>Aims:</b> Development of resistance by the malaria parasite, a systemic inflammatory and infectious pathogen, has raised the need for novel efficacious antimalarials. Plant-derived natural compounds are known to modulate the immune response and eradicate the infectious pathogens. Therefore we carried out experiments with swertiamarin to dissect its anti-inflammatory and immunomodulatory potential. <b>Materials &amp; methods:</b> We carried out studies in Swiss albino mice that received infectious challenge with <i>Plasmodium berghei</i> and swertiamarin treatment in a prophylactic manner. <b>Results &amp; conclusion:</b> Oral administration of swertiamarin prior to infectious challenge with <i>P. berghei</i> in experimental mice showed delayed parasite development as compared with untreated control. IFN-γ and IL-10 appeared to be adapted/modulated by regular swertiamarin treatment. Further, withdrawal of swertiamarin pressure did not affect parasite replication. However, the short half-life of swertiamarin limited its long-lasting therapeutic effect, requiring higher and frequent dosing schedules.
Keyphrases
  • plasmodium falciparum
  • immune response
  • anti inflammatory
  • protein kinase
  • toxoplasma gondii
  • high fat diet induced
  • dendritic cells
  • insulin resistance
  • combination therapy
  • life cycle
  • candida albicans
  • gram negative