Association between diffuse lymphocytic infiltration and papillary thyroid cancer aggressiveness according to the presence of thyroid peroxidase antibody and BRAFV600E mutation.
Young Ki LeeKyeong Hye ParkSe Hee ParkKwang Joon KimDong Yeob ShinKee Hyun NamWoong Youn ChungEun Jig LeePublished in: Head & neck (2018)
Although DLI was associated with multifocality regardless of TPOAb positivity, it was associated with an indolent feature when TPOAb was positive but with aggressive features in PTC with wild-type BRAF when TPOAb was negative. The TPOAb and BRAF status may help to define the clinical implication of lymphocytic infiltration found with PTC.