LINC00240 in the 6p22.1 risk locus promotes gastric cancer progression through USP10-mediated DDX21 stabilization.

Nasha ZhangBowen WangChi MaJiajia ZengTeng WangLinyu HanMing Yang

Published in: Journal of experimental & clinical cancer research : CR (2023)

Taken together, our data uncovered a new paradigm on how lncRNAs control protein deubiquitylation via intensifying interactions between the target protein and its deubiquitinase. These findings highlight the potentials of lncRNAs as innovative therapeutic targets and thus lay the ground work for clinical translation.

Keyphrases

protein protein
amino acid
long non coding rna
binding protein
network analysis
big data
long noncoding rna
genome wide analysis