DEP domain-containing mTOR-interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease.
Hanqing ChenFeng ShenAlex SherbanAllison NoconYu LiHua WangMing-Jiang XuXianliang RuiJinyan HanBingbing JiangDonghwan LeeNa LiFarnaz Keyhani-NejadJian-Gao FanFeng LiuAmrita KamatNicolas MusiLeonard GuarentePal PacherBin GaoMengwei ZangPublished in: Hepatology (Baltimore, Md.) (2018)
The dysregulation of SIRT1-DEPTOR-mTORC1 signaling is a critical determinant of ALD pathology; targeting SIRT1 and DEPTOR and selectively inhibiting mTORC1-S6K1 signaling may have therapeutic potential for treating ALD in humans. (Hepatology 2018).