The Efficacy of Cefazolin Versus Vancomycin Antibiotic Cement Spacers.

Cefazolin was not inactivated by PMMA polymerization and resulted in spacers with superior antimicrobial and biomechanical properties than those made with Vancomycin suggesting that Cefazolin could play a role in the treatment of infected bone defects with high-dose antibiotic PMMA spacers.