Nucleic Acid Delivery Nanotechnologies for In Vivo Cell Programming.
Hannia V BalcortaVeronica G Contreras GuerreroDeepali BishtWilson PoonPublished in: ACS applied bio materials (2024)
In medicine, it is desirable for clinicians to be able to restore function and imbue novel function into selected cells for therapy and disease prevention. Cells damaged by disease, injury, or aging could be programmed to restore normal or lost functions, such as retinal cells in inherited blindness and neuronal cells in Alzheimer's disease. Cells could also be genetically programmed with novel functions such as immune cells expressing synthetic chimeric antigen receptors for immunotherapy. Furthermore, knockdown or modification of risk factor proteins can mitigate disease development. Currently, nucleic acids are emerging as a versatile and potent therapeutic modality for achieving this cellular programming. In this review, we highlight the latest developments in nanobiomaterials-based nucleic acid therapeutics for cellular programming from a biomaterial design and delivery perspective and how to overcome barriers to their clinical translation to benefit patients.
Keyphrases
- induced apoptosis
- nucleic acid
- risk factors
- oxidative stress
- signaling pathway
- end stage renal disease
- cell therapy
- chronic kidney disease
- small molecule
- single cell
- palliative care
- prognostic factors
- ejection fraction
- diabetic retinopathy
- cognitive decline
- blood brain barrier
- bone marrow
- subarachnoid hemorrhage
- brain injury
- mild cognitive impairment
- peritoneal dialysis
- cerebral ischemia