The role of cell-free hemoglobin and haptoglobin in acute kidney injury in critically ill adults with ARDS and therapy with VV ECMO.
Jan Adriaan GrawPhilip HildebrandtAlexander KrannichFelix BalzerClaudia D SpiesRoland C E FrancisWolfgang M KueblerSteffen Weber-CarstensMario MenkOliver HunsickerPublished in: Critical care (London, England) (2022)
In critically ill patients with ARDS requiring therapy with VV ECMO, an increased plasma concentration of CFH was identified as independent risk factor for AKI. Among patients with increased CFH concentrations, higher plasma haptoglobin concentrations might protect from CFH-associated AKI and should be subject of future research.