Diffuse myocardial fibrosis precedes subclinical functional myocardial impairment and provides prognostic information in systemic sclerosis.

Alexander GotschySuzana JordanChristian T StoeckConstantin von DeusterTatiana PeerMareike GastlValery VishnevskiyLukas WissmannRucsandra DobrotaCarina MihaiMike O BeckerBritta MaurerSebastian KozerkeFrank RuschitzkaOliver DistlerRobert Manka

Published in: European heart journal. Cardiovascular Imaging (2022)

Subclinical myocardial involvement first manifests as diffuse myocardial fibrosis identified by the expansion of ECV and increased native T1 in VEDOSS patients while subtle functional impairment only occurs in established SSc. Native T1 and GLS have prognostic value for all-cause mortality in SSc patients.

Keyphrases

systemic sclerosis
end stage renal disease
left ventricular
ejection fraction
newly diagnosed
prognostic factors
interstitial lung disease
peritoneal dialysis
heart failure
atrial fibrillation