The Endothelin Receptor Antagonist Macitentan Improves Isosorbide-5-Mononitrate (ISMN) and Isosorbide Dinitrate (ISDN) Induced Endothelial Dysfunction, Oxidative Stress, and Vascular Inflammation.
Sebastian StevenMatthias OelzeMichael HausdingSiyer RoohaniFatemeh KashaniSwenja Kröller-SchönJohanna HelmstädterThomas JansenChristine BaumMarc IglarzEberhard SchulzThomas MünzelAndreas DaiberPublished in: Oxidative medicine and cellular longevity (2018)
ISMN/ISDN treatment caused activation of the NOX-2/ET receptor signaling axis leading to increased vascular oxidative stress and inflammation as well as endothelial dysfunction. Our study demonstrates for the first time that blockade of ET receptor signaling by the dual endothelin receptor blocker macitentan improves adverse side effects of the organic nitrates ISMN and ISDN.