Does anti-tumor necrosis factor alpha prevent the recurrence of Crohn's disease? Systematic review and meta-analysis.
Motoi UchinoHiroki IkeuchiKeisuke HataTomohiro MinagawaYuki HorioRyuichi KuwaharaShiro NakamuraKenji WatanabeMasayuki SarutaToshimitsu FujiiTaku KobayashiKen SugimotoFumihito HiraiMotohiro EsakiSakiko HiraokaKatsuyoshi MatsuokaShinichiro ShinzakiMinoru MatsuuraNagamu InoueHiroshi NakaseMamoru WatanabePublished in: Journal of gastroenterology and hepatology (2020)
Anti-TNF therapy after surgery for CD displays efficacy at preventing endoscopic recurrence for 1-2 years, without increasing the incidence of AEs. However, clinical recurrence was not significantly reduced. The efficacy of postoperative anti-TNF therapy may differ in terms of the outcomes, which include long-term prevention, the avoidance of further surgery, and cost-effectiveness.