Basic fibroblast growth factor reduces scar by inhibiting the differentiation of epidermal stem cells to myofibroblasts via the Notch1/Jagged1 pathway.

Peng WangBin ShuYingbin XuJiayuan ZhuJian LiuZiheng ZhouLei ChenJingling ZhaoXusheng LiuShaohai QiKun XiongJulin Xie

Published in: Stem cell research & therapy (2017)

These results provide evidence that bFGF can reduce scar by inhibiting the differentiation of ESCs to MFB via the Notch1/Jagged1 pathway, and present a new promising potential direction for the treatment of scar.

Keyphrases

stem cells
wound healing
signaling pathway
cell proliferation
risk assessment
human health
climate change
smoking cessation