A haplotype-resolved genome assembly of the Nile rat facilitates exploration of the genetic basis of diabetes.

Huishi TohChentao YangGiulio FormentiKalpana RajaLily YanAlan TraceyWilliam ChowKerstin HoweLucie A BergeronGuojie ZhangBettina HaaseJacquelyn MountcastleOlivier FedrigoJohn FoggBogdan KirilenkoChetan MunegowdaMichael HillerAashish JainDaisuke KiharaArang RhieAdam M PhillippyScott A SwansonPeng JiangDennis O CleggErich D JarvisJames A ThomsonRon StewartMark J P ChaissonYury V Bukhman

Published in: BMC biology (2022)

Our findings reflect the exceptional level of genomic resolution present in this assembly, which will greatly expand the potential of the Nile rat as a model organism.

Keyphrases

oxidative stress
genome wide
copy number
type diabetes
cardiovascular disease
glycemic control
risk assessment
dna methylation
human health
adipose tissue
insulin resistance