Genetic risk of dementia mitigated by cognitive reserve: A cohort study.

Serhiy DekhtyarAnna MarsegliaWeili XuAlexander Darin-MattssonHui-Xin WangLaura Fratiglioni

Published in: Annals of neurology (2019)

Lifelong engagement in reserve-enhancing activities attenuates the risk of dementia attributable to APOE-ε4. Promoting cognitive reserve might be especially effective in subpopulations with high genetic risk of dementia. ANN NEUROL 2019.

Keyphrases

mild cognitive impairment
cognitive impairment
cognitive decline
genome wide
copy number
social media
high fat diet
metabolic syndrome
adipose tissue
gene expression
neural network