Effects of Functionalized Fullerenes on ROS Homeostasis Determine Their Cytoprotective or Cytotoxic Properties.
Svetlana V KostyukElena V ProskurninaEkaterina A SavinovaElizaveta S ErshovaOlga A KraevayaLarisa V KamenevaPavel E UmryukhinOlga A DolgikhSergey I KutsevPavel A TroshinNatalia N VeikoPublished in: Nanomaterials (Basel, Switzerland) (2020)
The intracellular effects of ethylphenylmalonate C70 derivative (FF1) can be explained in terms of upregulated NOX4 activity. The intracellular effects of thienylacetate C70 derivative (FF2) can be probably resulted from its superoxide scavenging potential and inhibition of lipid peroxidation. FF1 can be considered a NOX4 upregulator and potential cytotoxicant and FF2, as a superoxide scavenger and a potential cytoprotector.