Engineered CAR-T cells targeting the non-functional P2X purinoceptor 7 (P2X7) receptor as a novel treatment for ovarian cancer.

Veronika BandaraVictoria M NiktarasVasiliki J WillettHayley ChapmanNoor A LokmanAnne M MacphersonSilvana NapoliBatjargal GundsambuuJade FoengTimothy J SadlonJustin CoombsShaun R McCollSimon C BarryMartin K OehlerCarmela Ricciardelli

Published in: Clinical & translational immunology (2024)

This study demonstrates that nfP2X7-CAR-T cells have great potential to be developed as a novel immunotherapy for ovarian cancer.

Keyphrases

induced apoptosis
cell cycle arrest
cancer therapy
oxidative stress
cell proliferation
risk assessment
climate change
human health